Lots of things here. I wrote up a fun little tick-tock.
On macOS Sierra Version 10.12.5 on a MacBook Pro 15in, 2016 (same issues occur on a late-2013 MacPro running the same OS)
06/08/17 2PM PST:
When CC Application Manager auto updated to 4.1.1.202 no existing Premiere files would open. I had to create new, import the entire project. I couldn't use Media Encoder because when it tries to go back to Premiere it crashes. When I try to open the Premiere project it freezes when the media is loading, does it on two machines connected to the same content. If I save the new project (with the imported old project) it would crash when trying to re-open. Reinstalled Premiere & Media Encoder.
06/08/17 5PM PST:
Per a recommendation from Adobe Customer Care on Twitter I created a new user account and all files opened just fine. With this, I completely uninstalled the entire Adobe suite, Application Manager, Preferences, anything labeled "adobe" in the user folder. Restarted, reinstalled and everything started to work again on my main, admin user. Installed Premiere, After Effects, InDesign, Illustrator, Photoshop
06/09/17 9AM PST:
All seems fine, except when I try to open a dynamic linked After Effects comp in Premiere. As soon as I'd right click, Premiere would crash or if I hit a Menu Bar item it would crash. Uninstalled After Effects, Photoshop, Illustrator & InDesign, and leaving only Premiere / Media Encoder and everything works again.
06/09/17 10AM PST:
Reinstalled After Effects. No crashes. Dynamic Linked files open fine.
06/09/17 12:30PM PST:
After doing work in AE and Premiere, after trying to bring in a new After Effects comp VIA Dynamic Link it crashes. Whenever I try to scrub over previously linked material, it crashes. Premiere reads all After Effects comps as "Pending". When I try to manually relink, Premiere crashes.
06/09/17 12:55PM PST:
When I start a completely new project and try to import the effected project back into Premiere, it hangs and crashes.
This all started when the CC Application Manager auto-updated yesterday morning. No other system changes have occur from 06/07/17 when things were working to 06/08/17-- that's the only change.